Recombinant人Uroplakin III protein (ab115705)

概述

  • 产品名称
    Recombinant人Uroplakin III protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMGSHMVNLQPQLASVTFATNNPTLTTVALE KPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTE GGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCL WDPNFQGLCNPPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTP YSTIDTWPGRRSGG
    • 分子量
      23 kDa including tags
    • 氨基酸
      19 to 207
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab115705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab115705 is purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 0.88% Sodium chloride

常规信息

  • 别名
    • MGC119178
    • OTTHUMP00000028951
    • UP III
    • UP3a
    • UPIII
    • UPIIIA
    • UPK 3
    • UPK 3A
    • UPK3
    • UPK3A
    • UPK3A_HUMAN
    • Uroplakin 3A
    • Uroplakin III
    • Uroplakin-3a
    • Uroplakin3A
    • UroplakinIII
    see all
  • 功能
    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
  • 组织特异性
    Expressed in ureter.
  • 疾病相关
    Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
  • 序列相似性
    Belongs to the uroplakin-3 family.
  • 细胞定位
    Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab115705 at approximately 23.1kDa (3µg).

文献

ab115705 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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