Recombinant人UNC5B protein (ab109066)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionQ8IZJ1
    • 种属Human
    • 分子量80 kDa
    • 氨基酸28 to 363

技术指标

Our Abpromise guarantee covers the use of ab109066 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.

  • 形式Lyophilised
  • 补充说明Binds to Mouse and Human Netrin 1.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • 复溶Reconstitute with 50 µl sterile water.

常规信息

  • 别名
    • 6330415E02Rik
    • A630020F16
    • D10Bwg0792e
    • Netrin receptor UNC5B
    • Netrin receptor UNC5B Precursor
    • p53 regulated receptor for death and life
    • p53 regulated receptor for death and life protein 1
    • p53-regulated receptor for death and life protein 1
    • p53RDL1
    • Protein unc-5 homolog 2
    • Protein unc-5 homolog B
    • Protein XUNC 5
    • Transmembrane receptor Unc5H2
    • Unc 5 homolog 2
    • Unc 5 homolog B
    • Unc 5 netrin receptor B
    • UNC 5B
    • Unc5 (C.elegans homolog) b
    • Unc5b
    • UNC5B_HUMAN
    • UNC5H2
    see all
  • 功能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 组织特异性Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • 序列相似性Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • 翻译后修饰Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • 细胞定位Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt

Recombinant Human UNC5B protein (ab109066)参考文献

ab109066 has not yet been referenced specifically in any publications.

Product Wall

I can confirm that is ab109066 an Fc-Protein. The extracellular region of human UNC5B (aa 28-363) is fused at the C-terminus to the Fc portion of human IgG1.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"