Recombinant人UHRF1 protein (ab112411)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ96T88
    • 种属Human
    • 序列WNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNV CKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR
    • 分子量37 kDa including tags
    • 氨基酸694 to 793

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技术指标

Our Abpromise guarantee covers the use of ab112411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This product is useful for Antibody Production and Protein Array
  • 应用

    Western blot

    ELISA

    Peptide Array

  • 形式Liquid
  • 补充说明This product is useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced.

常规信息

  • 别名
    • Ac2-121
    • AL022808
    • E3 ubiquitin-protein ligase UHRF1
    • EC 6.3.2.-
    • FLJ21925
    • hNP95
    • hUHRF1
    • HuNp95
    • ICBP90
    • Inverted CCAAT box binding protein of 90 kDa
    • Inverted CCAAT box binding protein, 90-kD
    • Inverted CCAAT box-binding protein of 90 kDa
    • Liver regeneration-related protein LRRG126
    • MGC138707
    • NP95
    • Nuclear phosphoprotein, 95-KD
    • Nuclear protein 95
    • Nuclear zinc finger protein Np95
    • RING finger protein 106
    • RNF106
    • Transcription factor ICBP90
    • Ubiquitin like containing PHD and RING finger domains protein 1
    • Ubiquitin like PHD and RING finger domain containing protein 1
    • Ubiquitin-like PHD and RING finger domain-containing protein 1
    • Ubiquitin-like protein containing PHD and RING finger domains 1
    • Ubiquitin-like with PHD and ring finger domains 1
    • Ubiquitin-like, containing PHD and RING finger domains, 1
    • Ubiquitin-like-containing PHD and RING finger domains protein 1
    • UHRF1
    • UHRF1_HUMAN
    see all
  • 功能Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
  • 组织特异性Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 PHD-type zinc finger.
    Contains 2 RING-type zinc fingers.
    Contains 1 ubiquitin-like domain.
    Contains 1 YDG domain.
  • 发展阶段Expressed in fetal thymus, liver and kidney.
  • 结构域The RING finger is required for ubiquitin ligase activity.
    The YDG domain mediates the interaction with histone H3.
  • 翻译后修饰Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
    Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human UHRF1 protein 图像

  • 12.5% SDS-PAGE image, using ab112411. (Stained with Coomassie Blue)

Recombinant Human UHRF1 protein (ab112411)参考文献

ab112411 has not yet been referenced specifically in any publications.

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