Recombinant人UBE2D2 protein (ab111451)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP62837
    • 种属Human
    • 分子量17 kDa
    • 氨基酸1 to 147
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab111451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab111451 is not susceptible to self-ubiquitinylation. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.
  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明ab111451 is not susceptible to self-ubiquitinylation. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.01% DTT

常规信息

  • 别名
    • E2(17)KB2
    • OTTHUMP00000223475
    • OTTHUMP00000223476
    • OTTHUMP00000223477
    • OTTHUMP00000223478
    • OTTHUMP00000224375
    • PUBC 1
    • PUBC1
    • UB2D2_HUMAN
    • UBC 4
    • UBC 4/5
    • UBC4
    • UBC4/5
    • UBC4/5 homolog yeast
    • UBCH 5B
    • UBCH5B
    • UBE2D2
    • Ubiquitin carrier protein
    • Ubiquitin carrier protein D2
    • Ubiquitin conjugating enzyme E2 17 kDa 2
    • Ubiquitin conjugating enzyme E2 D2
    • Ubiquitin conjugating enzyme E2D 2
    • Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
    • Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast)
    • Ubiquitin protein ligase D2
    • Ubiquitin-conjugating enzyme E2 D2
    • Ubiquitin-conjugating enzyme E2(17)KB 2
    • Ubiquitin-conjugating enzyme E2-17 kDa 2
    • Ubiquitin-protein ligase D2
    see all
  • 功能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
  • Information by UniProt

Recombinant Human UBE2D2 protein (ab111451)参考文献

ab111451 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111451.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"