Recombinant人UBE2D2 protein (ab111451)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      17 kDa
    • 氨基酸
      1 to 147
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab111451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    ab111451 is not susceptible to self-ubiquitinylation. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.
  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Liquid
  • 补充说明
    ab111451 is not susceptible to self-ubiquitinylation. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.01% DTT

常规信息

  • 别名
    • E2(17)KB2
    • OTTHUMP00000223475
    • OTTHUMP00000223476
    • OTTHUMP00000223477
    • OTTHUMP00000223478
    • OTTHUMP00000224375
    • PUBC 1
    • PUBC1
    • UB2D2_HUMAN
    • UBC 4
    • UBC 4/5
    • UBC4
    • UBC4/5
    • UBC4/5 homolog yeast
    • UBCH 5B
    • UBCH5B
    • UBE2D2
    • Ubiquitin carrier protein
    • Ubiquitin carrier protein D2
    • Ubiquitin conjugating enzyme E2 17 kDa 2
    • Ubiquitin conjugating enzyme E2 D2
    • Ubiquitin conjugating enzyme E2D 2
    • Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
    • Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast)
    • Ubiquitin protein ligase D2
    • Ubiquitin-conjugating enzyme E2 D2
    • Ubiquitin-conjugating enzyme E2(17)KB 2
    • Ubiquitin-conjugating enzyme E2-17 kDa 2
    • Ubiquitin-protein ligase D2
    see all
  • 功能
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the ubiquitin-conjugating enzyme family.
  • Information by UniProt

文献

ab111451 has not yet been referenced specifically in any publications.

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