Recombinant人UBE2D1 protein (Chemical Free) (ab81580)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 标签
      proprietary tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab81580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Conjugation

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Lyophilised
  • 补充说明

     Ubch5a has 89% and 88% sequence identity with Ubch5b and Ubch5c respectively. Typical enzyme concentration to support conjugation in vitro is 100 nM-1 μM depending on conditions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 50mM HEPES, 100mM Sodium chloride, 1mM DTT, pH 8.0

常规信息

  • 别名
    • E2(17)KB1
    • SFT
    • Stimulator of Fe transport
    • UB2D1_HUMAN
    • UBC 4/5
    • UBC4/5
    • UBC4/5 homolog
    • UBC4/5, S. cerevisiae, homolog of
    • UBCH 5
    • UBCH 5A
    • UbcH5
    • UBCH5A
    • Ube2d1
    • Ubiquitin carrier protein
    • Ubiquitin carrier protein D1
    • Ubiquitin conjugating enzyme E2 17 kDa 1
    • Ubiquitin conjugating enzyme E2 D1
    • Ubiquitin conjugating enzyme E2D 1
    • Ubiquitin conjugating enzyme E2D 1 (UBC4/5 homolog yeast)
    • Ubiquitin conjugating enzyme UBCH5A
    • Ubiquitin protein ligase D1
    • Ubiquitin-conjugating enzyme E2 D1
    • Ubiquitin-conjugating enzyme E2(17)KB 1
    • Ubiquitin-conjugating enzyme E2-17 kDa 1
    • Ubiquitin-protein ligase D1
    see all
  • 功能
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of CHIP, TRAF6 and TRIM63/MURF1. Ubiquitinates CHIP-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
  • 组织特异性
    Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the ubiquitin-conjugating enzyme family.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

Recombinant Human UBE2D1 protein (Chemical Free) (ab81580)参考文献

ab81580 has not yet been referenced specifically in any publications.

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