Recombinant人UBE2C protein (ab59311)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab59311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 50mM HEPES, 125mM Sodium chloride, 1mM DTT, pH 8

常规信息

  • 别名
    • Cyclin selective ubiquitin carrier protein
    • dJ447F3.2
    • Mitotic specific ubiquitin conjugating enzyme
    • UB E2C
    • UBCH 10
    • UbcH10
    • UBE 2C
    • Ube2c
    • UBE2C_HUMAN
    • Ubiquitin carrier protein C
    • Ubiquitin carrier protein E2 C
    • Ubiquitin carrier protein E2C
    • Ubiquitin conjugating enzyme E2 C
    • Ubiquitin conjugating enzyme E2C
    • Ubiquitin protein ligase C
    • Ubiquitin-conjugating enzyme E2 C
    • Ubiquitin-protein ligase C
    see all
  • 功能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
  • 翻译后修饰Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
  • Information by UniProt

Recombinant Human UBE2C protein (ab59311)参考文献

ab59311 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us yesterday and sorry for the delay in getting back to you.

As discussed over the phone, unfortunately, the biological activity of the UBE2C protein (His tag) (ab59311) has not been tested by us and we have no report...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"