Recombinant人UBE1C protein (ab123194)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MGSHMADGEE PERKRRRIEE LLAEKMAVDG GCGDTGDWEG RWNHVKKFLE RSGPFTHPDF EPSTESLQFL LDTCKVLVIG AGGLGCELLK NLALSGFRQI HVIDMDTIDV SNLNRQFLFR PKDIGRPKAE VAAEFLNDRV PNCNVVPHFN KIQDFNDTFY RQFHIIVCGL DSIIARRWIN GMLISLLNYE DGVLDPSSIV PLIDGGTEGF KGNARVILPG MTACIECTLE LYPPQVNFPM CTIASMPRLP EHCIEYVRML QWPKEQPFGE GVPLDGDDPE HIQWIFQKSL ERASQYNIRG VTYRLTQGVV KRIIPAVAST NAVIAAVCAT EVFKIATSAY IPLNNYLVFN DVDGLYTYTF EAERKENCPA CSQLPQNIQF SPSAKLQEVL DYLTNSASLQ MKSPAITATL EGKNRTLYLQ SVTSIEERTR PNLSKTLKEL GLVDGQELAV ADVTTPQTVL FKLHFTS
    • 分子量
      54 kDa including tags
    • 氨基酸
      1 to 463
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.
    ab123194 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • DKFZp566J164
    • EC 6.3.2.
    • hUba3
    • MGC22384
    • NEDD8 activating enzyme E1 catalytic subunit
    • NEDD8 activating enzyme E1C
    • Nedd8 activating enzyme hUba3
    • NEDD8-activating enzyme E1 catalytic subunit
    • NEDD8-activating enzyme E1C
    • uba3
    • UBA3 ubiquitin activating enzyme E1 homolog
    • UBA3_HUMAN
    • UBE1C
    • Ubiquitin activating enzyme 3
    • Ubiquitin activating enzyme E1C
    • Ubiquitin-activating enzyme 3
    • Ubiquitin-activating enzyme E1C
    • Ubiquitin-like modifier-activating enzyme 3
    see all
  • 功能
    Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
  • 组织特异性
    Ubiquitously expressed.
  • 通路
    Protein modification; protein neddylation.
  • 序列相似性
    Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab123194 (3µg).

文献

ab123194 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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