Recombinant人TYK2 protein (ab112369)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      PVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQ WWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWA
    • 分子量
      37 kDa including tags
    • 氨基酸
      276 to 375

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技术指标

Our Abpromise guarantee covers the use of ab112369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    ab112369 is best used within three months from the date of receipt.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • JTK 1
    • JTK1
    • Non receptor tyrosine protein kinase 2
    • Non receptor tyrosine protein kinase TYK2
    • Non-receptor tyrosine-protein kinase TYK2
    • OTTHUMP00000232745
    • OTTHUMP00000232746
    • OTTHUMP00000232748
    • Protein Tyrosine Kinase 2
    • TYK 2
    • Tyk2
    • TYK2_HUMAN
    • Tyrosine kinase 2
    see all
  • 功能
    Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
  • 组织特异性
    Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
  • 疾病相关
    Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
    Contains 1 FERM domain.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
  • 结构域
    The FERM domain mediates interaction with JAKMIP1.
  • Information by UniProt

图片

  • ab112369 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

文献

ab112369 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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