The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性useful for Antibody Production and Protein Array
补充说明ab112369 is best used within three months from the date of receipt.useful for Antibody Production and Protein Array
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
Non receptor tyrosine protein kinase 2
Non receptor tyrosine protein kinase TYK2
Non-receptor tyrosine-protein kinase TYK2
Protein Tyrosine Kinase 2
Tyrosine kinase 2
功能Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
组织特异性Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
疾病相关Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.
结构域The FERM domain mediates interaction with JAKMIP1.