Recombinant人Tropomyosin 2 protein (ab103503)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP07951-2
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMDAIKKKMQMLKLDKENAIDRAEQAEADKK QAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI ENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSE ERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEEEIKLLEE KLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLE LNNL
    • 分子量35 kDa including tags
    • 氨基酸1 to 284
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab103503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab103503 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Alpha tropomyosin
    • AMCD1
    • Arthrogryposis multiplex congenital distal type 1
    • Beta tropomyosin
    • Beta-tropomyosin
    • Cytoskeletal tropomyosin TM30
    • DA1
    • DA2B
    • epididymis secretory protein Li 273
    • FLJ41118
    • Heat stable cytoskeletal protein 30 kDa
    • HEL-S-273
    • hscp30
    • HTM alpha
    • hTM5
    • MGC14582
    • MGC3261
    • MGC72094
    • NEM1
    • NEM4
    • Nemaline myopathy type 4
    • OK/SW cl.5
    • Sarcomeric tropomyosin kappa
    • TM 5
    • TM3
    • TM30
    • TM30nm
    • TMSA
    • TMSB
    • TPM 1
    • TPM 3
    • TPM1 alpha
    • TPM1 kappa
    • TPM2
    • TPM2_HUMAN
    • TRK
    • Tropomyosin 1 alpha
    • Tropomyosin 1 alpha chain
    • Tropomyosin 1 alpha chain isoform 6
    • Tropomyosin 2
    • Tropomyosin 2 (beta)
    • Tropomyosin 3
    • Tropomyosin alpha 3 chain
    • Tropomyosin alpha striated muscle isoform
    • Tropomyosin beta chain
    • Tropomyosin gamma
    • Tropomyosin skeletal muscle beta
    • Tropomyosin-2
    see all
  • 功能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
  • 组织特异性Present in primary breast cancer tissue, absent from normal breast tissue.
  • 疾病相关Nemaline myopathy 4 (NEM4) [MIM:609285]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Arthrogryposis, distal, 1A (DA1A) [MIM:108120]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the tropomyosin family.
  • 结构域The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • 翻译后修饰Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Tropomyosin 2 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab103503.

Recombinant Human Tropomyosin 2 protein (ab103503)参考文献

ab103503 has not yet been referenced specifically in any publications.

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