Recombinant人Tropomyosin 1 (alpha) protein (ab99214)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP09493
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMDAIKKKMQMLKLDKENALDRAEQAEADKK AAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATD AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI ESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE ERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSD KLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALND MTSM
    • 分子量35 kDa including tags
    • 氨基酸1 to 284
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab99214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab99214 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • AA986836
    • AI854628
    • Alpha tropomyosin
    • alpha-TM
    • Alpha-tropomyosin
    • C15orf13
    • cardiomyopathy, hypertrophic 3
    • CMD1Y
    • CMH3
    • HTM alpha
    • HTM-alpha
    • OTTHUMP00000163688
    • sarcomeric tropomyosin kappa
    • TM2
    • Tmpa
    • TMSA
    • Tpm-1
    • TPM1
    • TPM1_HUMAN
    • Tropomyosin 1
    • tropomyosin 1 (alpha)
    • tropomyosin 1 (alpha) isoform 1
    • tropomyosin 1 (alpha) isoform 2
    • tropomyosin 1 (alpha) isoform 3
    • tropomyosin 1 (alpha) isoform 4
    • tropomyosin 1 (alpha) isoform 5
    • tropomyosin 1 (alpha) isoform 6
    • tropomyosin 1 (alpha) isoform 7
    • Tropomyosin alpha 1 chain
    • Tropomyosin alpha-1 chain
    • Tropomyosin, skeletal muscle alpha
    • Tropomyosin-1
    see all
  • 功能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • 组织特异性Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
  • 疾病相关Defects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TPM1 are the cause of cardiomyopathy dilated type 1Y (CMD1Y) [MIM:611878]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性Belongs to the tropomyosin family.
  • 结构域The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Tropomyosin 1 (alpha) protein 图像

  • 15% SDS-PAGE analysis of 3µg ab99214.

Recombinant Human Tropomyosin 1 (alpha) protein (ab99214)参考文献

ab99214 has not yet been referenced specifically in any publications.

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