概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      455 to 822

相关产品

技术指标

Our Abpromise guarantee covers the use of ab56652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式
    Liquid
  • 补充说明

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • AI848316
    • BDNF tropomyosine receptor kinase B
    • BDNF/NT 3 growth factors receptor
    • BDNF/NT-3 growth factors receptor
    • Brain derived neurotrophic factor receptor
    • C030027L06Rik
    • EC 2.7.10.1
    • GP145 TrkB
    • GP145-TrkB
    • GP145-TrkB/GP95-TrkB
    • GP95 TrkB
    • Neurotrophic receptor tyrosine kinase 2
    • Neurotrophic tyrosine kinase receptor type 2
    • Neurotrophin receptor tyrosine kinase type 2
    • NTRK 2
    • Ntrk2
    • NTRK2_HUMAN
    • Obesity, hyperphagia, and developmental delay, included
    • RATTRKB1
    • Tkrb
    • Trk B
    • Trk-B
    • TRKB
    • TrkB tyrosine kinase
    • TRKB1
    • Tropomyosin related kinase B
    • tyrosine kinase receptor B
    • Tyrosine receptor kinase B
    see all
  • 功能
    Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
  • 组织特异性
    Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Ligand-mediated auto-phosphorylation.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • Kinase Assay; Specific Activity 74nmol/min/mg
  • SDS Page analysis of ab56652.

文献

This product has been referenced in:
  • Wessels JM  et al. The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (Ntrk2) are conserved in the mammalian uterus. PLoS One 9:e94036 (2014). Read more (PubMed: 24714156) »

See 1 Publication for this product

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