Recombinant人Tristetraprolin protein (ab112374)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP26651
    • 种属Human
    • 序列MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSDSSPSGV TSRLPGRSTSLVEGRSCGWVPPPPGFAPLAPRLGPELSPSPTSPTATSTT PSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKF YLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQSISFSGLPSGRRTSPPP PGLAGPSLSSSSFSPSSSPPPPGDLPLSPSAFSAAPGTPLARRDPTPVCC PSCRRATPISVWGPLGGLVRTPSVQSLGSDPDEYASSGSSLGGSDSPVFE AGVFAPPQPVAAPRRLPIFNRISVSE
    • 分子量62 kDa including tags
    • 氨基酸1 to 326

技术指标

Our Abpromise guarantee covers the use of ab112374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明ab112374 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • G0/G1 switch regulatory protein 24
    • G0S24
    • GOS24
    • Growth factor-inducible nuclear protein NUP475
    • NUP475
    • Protein TIS11A
    • RNF162A
    • TIS 11
    • TIS11
    • TIS11A
    • Tristetraprolin
    • Tristetraproline
    • TTP
    • TTP_HUMAN
    • Zfp-36
    • ZFP36
    • Zinc finger protein 36
    • Zinc finger protein 36 homolog
    • Zinc finger protein 36, C3H type, homolog (mouse)
    • Zinc finger protein, C3H type, 36 homolog
    see all
  • 功能mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
  • 序列相似性Contains 2 C3H1-type zinc fingers.
  • 翻译后修饰Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
  • 细胞定位Nucleus. Cytoplasm. Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
  • Information by UniProt

Recombinant Human Tristetraprolin protein 图像

  • ab112374 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human Tristetraprolin protein (ab112374)参考文献

ab112374 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112374.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"