Recombinant人TRIM72 protein (ab112438)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ6ZMU5
    • 种属Human
    • 序列QGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFY DASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAE
    • 分子量37 kDa including tags
    • 氨基酸378 to 477

技术指标

Our Abpromise guarantee covers the use of ab112438 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This product is useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Peptide Array

    Western blot

  • 形式Liquid
  • 补充说明This product is useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced.

常规信息

  • 别名
    • LOC493829
    • Mg53
    • Mitsugumin-53
    • TRI72_HUMAN
    • trim72
    • Tripartite motif containing 72
    • Tripartite motif containing protein 72
    • Tripartite motif-containing protein 72
    see all
  • 功能Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
  • 序列相似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 翻译后修饰Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
  • 细胞定位Cell membrane > sarcolemma. Cytoplasmic vesicle membrane. Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
  • Information by UniProt

Recombinant Human TRIM72 protein 图像

  • 12.5% SDS-PAGE showing ab112438 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human TRIM72 protein (ab112438)参考文献

ab112438 has not yet been referenced specifically in any publications.

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