The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
ADP ribosylation factor domain protein 1
ADP-ribosylation factor domain-containing protein 1
ARF domain protein 1
E3 ubiquitin-protein ligase TRIM23
GTP binding protein ARD 1
GTP-binding protein ARD-1
N-acetyltransferase ARD1 human homolog of
N-acetyltransferase homolog of S. cerevisiae ARD1
RING finger protein 46
Tripartite motif protein TRIM23
Tripartite motif-containing protein 23
功能Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
通路Protein modification; protein ubiquitination.
序列相似性In the C-terminal section; belongs to the small GTPase superfamily. Arf family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger.
结构域The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
细胞定位Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Membrane-associated with the Golgi complex and lysosomal structures.