Recombinant人TRIB3 protein (ab112420)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ96RU7
    • 种属Human
    • 序列MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPL SPPTAPDRATAVATASRLGPYVLLEPEEGGRAYRALHCPTGTEYTCKVYP VQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRS RHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVL ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVA LFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEG DREVVLYG
    • 分子量65 kDa including tags
    • 氨基酸1 to 358

技术指标

Our Abpromise guarantee covers the use of ab112420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • C20orf97
    • Neuronal cell death inducible putative kinase
    • Neuronal cell death-inducible putative kinase
    • NIPK
    • p65 interacting inhibitor of NF-kappaB
    • p65-interacting inhibitor of NF-kappa-B
    • SINK
    • SKIP 3
    • SKIP3
    • TRB 3
    • TRB-3
    • TRB3
    • TRIB 3
    • Trib3
    • TRIB3_HUMAN
    • Tribbles homolog 3
    • Tribbles pseudokinase 3
    • Tribbles3
    see all
  • 功能Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
  • 组织特异性Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human TRIB3 protein 图像

  • ab112420 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human TRIB3 protein (ab112420)参考文献

ab112420 has not yet been referenced specifically in any publications.

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