Recombinant人Transportin 1 protein (ab114514)

概述

  • 产品名称Recombinant人Transportin 1 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ92973-2
    • 种属Human
    • 序列PDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKN NVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQ NWPDLLPKLCSLLDSED*
    • 分子量39 kDa including tags
    • 氨基酸25 to 141

技术指标

Our Abpromise guarantee covers the use of ab114514 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Importin 2
    • Importin beta 2
    • Importin beta-2
    • IPO 2
    • IPO2
    • Karyopherin (importin) beta 2
    • Karyopherin beta 2
    • Karyopherin beta-2
    • KPN B2
    • KPNB 2
    • KPNB2
    • M9 interacting protein
    • M9 region interacting protein
    • M9 region interaction protein
    • MIP
    • MIP 1
    • MIP1
    • OTTHUMP00000126960
    • OTTHUMP00000222024
    • OTTHUMP00000226224
    • TNPO 1
    • Tnpo1
    • TNPO1_HUMAN
    • Transportin
    • Transportin 1
    • Transportin-1
    • Transportin1
    • TRN
    see all
  • 功能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
  • 序列相似性Belongs to the importin beta family.
    Contains 8 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human Transportin 1 protein 图像

  • ab114514 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human Transportin 1 protein (ab114514)参考文献

ab114514 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114514.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"