Recombinant人TRAF1 protein (ab117184)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ13077
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMDGTFLWKITNVTRRCHESACGRTVSLFSP AFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQ SPKHAYVKDDTMFLKCIVETST
    • 分子量20 kDa
    • 氨基酸266 to 416
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab117184 is purified by standard chromatography.
  • 形式Liquid
  • 补充说明Although stable at 4°C for 1 week, ab117184 should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

��备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 0.02% DTT, 20% Glycerol

常规信息

  • 别名
    • 4732496E14Rik
    • EBI6
    • EBV induced protein 6
    • Epstein-Barr virus-induced protein 6
    • MGC:10353
    • Tnf receptor associated factor 1
    • TNF receptor-associated factor 1
    • TRAF 1
    • TRAF1
    • TRAF1_HUMAN
    see all
  • 功能Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
  • 序列相似性Contains 1 MATH domain.
  • 结构域The coiled coil domain mediates homo- and hetero-oligomerization.
    The MATH/TRAF domain binds to receptor cytoplasmic domains.
    Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
  • 翻译后修饰Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
  • Information by UniProt

Recombinant Human TRAF1 protein (ab117184)参考文献

ab117184 has not yet been referenced specifically in any publications.

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