Recombinant人TNFRSF1A protein (ab109144)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionP19438
    • 种属Human
    • 分子量60 kDa including tags
    • 氨基酸22 to 211

技术指标

Our Abpromise guarantee covers the use of ab109144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab109144 blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1µg/ml. Binds Human and Mouse TNF-alpha.
  • 应用

    Functional Studies

    SDS-PAGE

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.

  • 形式Lyophilised
  • 补充说明After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Reconstitute with 50µl sterile water to give a final concentration of 1mg/ml.

常规信息

  • 别名
    • CD120a
    • FPF
    • MGC19588
    • p55
    • p55 R
    • P55R
    • p60
    • TBP 1
    • TBP1
    • TBPI
    • TNF R
    • TNF R I
    • TNF R55
    • TNF-R1
    • TNF-RI
    • TNFAR
    • TNFR
    • TNFR 55
    • TNFR 60
    • TNFR-I
    • TNFR1
    • TNFR55
    • TNFR60
    • TNFRI
    • TNFRSF1A
    • TNR1A_HUMAN
    • Tumor necrosis factor alpha receptor
    • Tumor necrosis factor binding protein 1
    • Tumor necrosis factor receptor 1
    • Tumor necrosis factor receptor superfamily member 1A
    • Tumor necrosis factor receptor type 1
    • Tumor necrosis factor receptor type I
    • Tumor necrosis factor-binding protein 1
    see all
  • 功能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • 疾病相关Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
  • 序列相似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 结构域The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • 翻译后修饰The soluble form is produced from the membrane form by proteolytic processing.
  • 细胞定位Cell membrane. Secreted.
  • Information by UniProt

Recombinant human TNFRSF1A protein (ab109144)参考文献

ab109144 has not yet been referenced specifically in any publications.

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