The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Best use within three months from the date of receipt of this protein.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Toll like receptor 2
Toll like receptor 2 precursor
Toll-like receptor 2
Toll/interleukin 1 receptor like 4
Toll/interleukin 1 receptor like protein 4
Toll/interleukin receptor like protein 4
Toll/interleukin-1 receptor-like protein 4
功能Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
组织特异性Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
序列相似性Belongs to the Toll-like receptor family. Contains 14 LRR (leucine-rich) repeats. Contains 1 TIR domain.
翻译后修饰Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.