Recombinant人TIP30 protein (ab98078)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9BUP3
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMAETEALSKLREDFRMQNKSVFILGASGET GRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYAS AFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLL SSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG EWLVRKFFGSLPDSWARGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAI HDLGKAHGSLKP
    • 分子量29 kDa including tags
    • 氨基酸1 to 242
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab98078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度>= 95 % SDS-PAGE.
    ab98078 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • 30 kDa HIV 1 TAT interacting protein
    • 30 kDa HIV-1 TAT-interacting protein
    • 30 kDa HIV1 TAT interacting protein
    • CC3
    • FLJ26963
    • HIV 1 Tat interacting protein 2
    • HIV 1 Tat interacting protein 2 30kDa
    • HIV-1 TAT-interactive protein 2
    • HTAI2_HUMAN
    • HTATIP 2
    • HTATIP2
    • Oxidoreductase HTATIP2
    • SDR44U1
    • Short chain dehydrogenase/reductase family 44U member 1
    • Tat interacting protein (30kDa)
    see all
  • 功能Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
  • 组织特异性Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
  • 结构域Unique C-terminus confers high proteasome-dependent instability to isoform 2.
  • 细胞定位Cytoplasm. Nucleus envelope.
  • Information by UniProt

Recombinant Human TIP30 protein 图像

  • 15% SDS-PAGE analysis of 3 µg ab98078

Recombinant Human TIP30 protein (ab98078)参考文献

ab98078 has not yet been referenced specifically in any publications.

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