Recombinant人TICAM2 protein (ab123160)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ86XR7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMGIGKS KINSCPLSLS WGKRHSVDTS PGYHESDSKK SEDLSLCNVA EHSNTTEGPT GKQEGAQSVE EMFEEEAEEE VFLKFVILHA EDDTDEALRV QNLLQDDFGI KPGIIFAEMP CGRQHLQNLD DAVNGSAWTI LLLTENFLRD TWCNFQFYTS LMNSVNRQHK YNSVIPMRPL NNPLPRERTP FALQTINALE EESRGFPTQV ERIFQESVYK TQQTIWKETR NMVQRQFIA
    • 分子量29 kDa including tags
    • 氨基酸1 to 235
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 85 % SDS-PAGE.
    ab123160 was purified using conventional chromatography techniques and is >85% pure by SDS PAGE.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Putative NF-kappa-B-activating protein 502
    • TCAM2_HUMAN
    • TICAM-2
    • TICAM2
    • TIR containing adapter molecule 2
    • TIR domain containing adaptor protein
    • TIR domain-containing adapter molecule 2
    • TIRAP 3
    • TIRAP3
    • TIRAP3a short form
    • TIRP
    • Toll-like receptor adaptor protein 3
    • Toll/interleukin-1 receptor domain-containing protein
    • TRAM
    • TRIF-related adapter molecule
    see all
  • 功能Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 组织特异性Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 序列相似性Contains 1 TIR domain.
  • 结构域The TIR domain mediates the interaction with TRAF6.
  • 翻译后修饰Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 细胞定位Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt

Recombinant Human TICAM2 protein 图像

  • 15% SDS-PAGE analysis of 3 µg of Human TICAM2 protein (ab123160).
    Note: Molecular size on SDS PAGE will appear higher.

Recombinant Human TICAM2 protein (ab123160)参考文献

ab123160 has not yet been referenced specifically in any publications.

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