Recombinant人Thyroid Peroxidase protein (ab73765)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 分子量101 kDa including tags
    • 额外的序列信息Glycosylated polypeptide chain containing 834 amino acids and having a molecular mass of 92.9 kDa (excluding glycosylation), 101 kDa total mass. The specific sequence information is proprietary.

技术指标

Our Abpromise guarantee covers the use of ab73765 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab73765 is purified by proprietary chromatographic techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 160mM Sodium chloride, 16mM HEPES, 0.08mM Kl, pH 7.6

常规信息

  • 别名
    • MSA
    • PERT_HUMAN
    • TDH2A
    • Thyroid microsomal antigen
    • Thyroid peroxidase
    • Thyroperoxidase
    • TPO
    • TPX
    see all
  • 功能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • 通路Hormone biosynthesis; thyroid hormone biosynthesis.
  • 疾病相关Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 序列相似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻译后修饰Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 细胞定位Membrane and Cell surface.
  • Information by UniProt

Recombinant Human Thyroid Peroxidase protein (ab73765)参考文献

ab73765 has not yet been referenced specifically in any publications.

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