Recombinant人Thyroid Hormone Receptor beta protein (ab82049)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 额外的序列信息This protein is His-tagged.

技术指标

Our Abpromise guarantee covers the use of ab82049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

常规信息

  • 别名
    • Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2
    • C ERBA 2
    • C ERBA BETA
    • c-erbA-2
    • c-erbA-beta
    • ERBA 2
    • ERBA BETA
    • ERBA2
    • Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian
    • generalized resistance to thyroid hormone
    • GRTH
    • MGC126109
    • MGC126110
    • NR1A2
    • Nuclear receptor subfamily 1 group A member 2
    • Oncogene ERBA2
    • PRTH
    • THB_HUMAN
    • THR1
    • thrB
    • THRB 1
    • THRB 2
    • THRB1
    • THRB2
    • Thyroid hormone nuclear receptor beta variant 1
    • Thyroid hormone receptor beta
    • Thyroid hormone receptor beta 1
    • Thyroid hormone receptor beta 2
    • Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian)
    see all
  • 功能High affinity receptor for triiodothyronine.
  • 疾病相关Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human Thyroid Hormone Receptor beta protein 图像

  • SDS-PAGE analysis of Human Thyroid Hormone Receptor beta full length protein (ab82049).

Recombinant Human Thyroid Hormone Receptor beta protein (ab82049)参考文献

ab82049 has not yet been referenced specifically in any publications.

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