序列Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
内毒素水平< 0.100 Eu/µg
补充说明The ED50, determined by the dose-dependent stimulation of the proliferation of the human MO7e cells, is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C mpl ligand
Megakaryocyte colony stimulating factor
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
Megakaryocyte stimulating factor
Myeloproliferative leukemia virus oncogene ligand
Thrombopoietin nirs variant 1
功能Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
疾病相关Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
序列相似性Belongs to the EPO/TPO family.
结构域Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.