Recombinant人THAP1 protein (denatured) (ab124553)

概述

  • 产品名称
    Recombinant人THAP1 protein (denatured)
  • 蛋白长度
    Full length protein
  • 描述
    Recombinant人THAP1 protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MGSHMVQSCS AYGCKNRYDK DKPVSFHKFP LTRPSLCKEW EAAVRRKNFK PTKYSSICSE HFTPDCFKRE CNNKLLKENA VPTIFLCTEP HDKKEDLLEP QEQLPPPPLP PPVSQVDAAI GLLMPPLQTP VNLSVFCDHN YTVEDTMHQR KRIHQLEQQV EKLRKKLKTA QQRCRRQERQ LEKLKEVVHF QKEKDDVSER GYVILPNDYF EIVEVPA
    • 分子量
      28 kDa including tags
    • 氨基酸
      1 to 213
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 85 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 12.01% Urea, 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • 4833431A01Rik
    • DYT6
    • FLJ10477
    • MGC33014
    • Nuclear proapoptotic factor
    • THAP 1
    • THAP domain containing 1
    • THAP domain containing apoptosis associated protein 1
    • THAP domain containing protein 1
    • THAP domain protein 1
    • THAP domain-containing protein 1
    • Thap1
    • THAP1_HUMAN
    see all
  • 功能
    DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
  • 疾病相关
    Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
  • 序列相似性
    Belongs to the THAP1 family.
    Contains 1 THAP-type zinc finger.
  • 细胞定位
    Nucleus > nucleoplasm. Nucleus > PML body.
  • Information by UniProt

图片

  • 15% SDS-PAGE (3 µg loaded)

文献

ab124553 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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