Recombinant人TGF beta 2 protein (ab84070)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • 种属Human
    • 序列ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

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技术指标

Our Abpromise guarantee covers the use of ab84070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Biological Activity : Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be = 0.2 ng/ml, corresponding to a specific activity of = 5 x 106 units/mg.
  • 应用

    Functional Studies

    SDS-PAGE

    Western blot

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.
    Purity is greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Reconstituted TGF beta 2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

常规信息

  • 别名
    • BSC-1 cell growth inhibitor
    • BSC1 cell growth inhibitor
    • Cetermin
    • G-TSF
    • Glioblastoma-derived T-cell suppressor factor
    • GTSF
    • LAP
    • Latency-associated peptide
    • MGC116892
    • MGF
    • Milk growth factor
    • Polyergin
    • TGF-beta-2
    • TGF-beta2
    • TGFB2
    • TGFB2_HUMAN
    • Transforming growth factor beta 2
    see all
  • 功能TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
  • 疾病相关A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
    Loeys-Dietz syndrome 4
    Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
  • 序列相似性Belongs to the TGF-beta family.
  • 翻译后修饰The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant human TGF beta 2 protein (ab84070)参考文献

This product has been referenced in:
  • Tran DQ  et al. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A 106:13445-50 (2009). Read more (PubMed: 19651619) »
  • O'Riordan E  et al. Chronic NOS inhibition actuates endothelial-mesenchymal transformation. Am J Physiol Heart Circ Physiol 292:H285-94 (2007). Read more (PubMed: 16963618) »

See all 2 Publications for this product

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Thank you for your enquiry.

Below is the instructions for the reconstitution of this product:


1. Centrifuge the vial prior to opening.

2. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex...

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Thank you for contacting us.

I can confirm that the product can be reconstituted with sterile water at conc. 0.1-1mg/ml.

Please note the concentration will depend on the amount of water you add. e.g. if 1ml is added the conc. will be ...

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Thank you for contacting Abcam regarding ab66045.


I am sorry that the caption describing the WB image was confusing. Please allow me to clarify:


The image represents a WB in which the antibody ab66045 was used to detect ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"