概述
- 产品名称Recombinant人TGF beta 1 protein
参阅全部 TGF beta 1 蛋白酶 - 蛋白长度Full length protein
描述
- 性质Recombinant
- 来源CHO cells
- 氨基酸序列
- 种属Human
- 序列ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
- 分子量25 kDa
- 额外的序列信息ab50038 composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
相关产品
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技术指标
Our Abpromise guarantee covers the use of ab50038 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 生物活性
The ED50 was determined by TGF beta 1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is < 0.05 ng/ml, corresponding to a specific activity of >2 x 107 units/mg
- 应用
SDS-PAGE
Functional Studies
- 形式Lyophilised
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Concentration information loading...
制备和贮存
- 稳定性和存储
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 复溶Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1- 1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
常规信息
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别名
- Cartilage-inducing factor
- CED
- Differentiation inhibiting factor
see all - 功能Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
- 组织特异性Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
- 疾病相关Defects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
- 序列相似性Belongs to the TGF-beta family.
- 翻译后修饰Glycosylated.
The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive. - 细胞定位Secreted > extracellular space > extracellular matrix.
- Information by UniProt
Recombinant human TGF beta 1 protein (ab50038)参考文献
ab50038 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"