Recombinant人TFII I protein (ab114786)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • 种属Human
    • 序列ELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEE KAAEMHKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVP VPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIK RPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMA AVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEVPAEG
    • 分子量52 kDa including tags
    • 氨基酸36 to 274

技术指标

Our Abpromise guarantee covers the use of ab114786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BAP 135
    • BAP-135
    • BAP135
    • Bruton tyrosine kinase associated protein 135
    • Bruton tyrosine kinase-associated protein 135
    • BTK associated protein
    • BTK associated protein 135
    • BTK associated protein 135kD
    • BTK-associated protein 135
    • BTKAP 1
    • BTKAP1
    • DIWS
    • FLJ38776
    • FLJ56355
    • General transcription factor II i
    • General transcription factor II-I
    • General transcription factor IIi
    • GTF 2I
    • Gtf2i
    • GTF2I_HUMAN
    • GTFII I
    • GTFII-I
    • IB 291
    • IB291
    • SPIN
    • SRF Phox 1 interacting protein
    • SRF Phox1 interacting protein
    • SRF-Phox1-interacting protein
    • TFII-I
    • Transcription factor II I
    • WBS
    • WBSCR 6
    • WBSCR6
    • Williams Beuren syndrome chromosome region 6
    • Williams Beuren syndrome chromosome region 6 protein
    • Williams-Beuren syndrome chromosomal region 6 protein
    see all
  • 功能Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
  • 组织特异性Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
  • 疾病相关Note=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 序列相似性Belongs to the TFII-I family.
    Contains 6 GTF2I-like repeats.
  • 翻译后修饰Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.
    Sumoylated.
  • 细胞定位Cytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm.
  • Information by UniProt

Recombinant Human TFII I protein 图像

  • ab114786 on 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human TFII I protein (ab114786)参考文献

ab114786 has not yet been referenced specifically in any publications.

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