Recombinant人TFB1M protein (ab113141)

概述

  • 产品名称
    Recombinant人TFB1M protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMQAAKQLSQNFLLDLRLTDKIVRKAGNLTN AYVYEVGPGPGGITRSIL NADVAELLVVEKDTRFIPGLQMLSDAAPGK LRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTP LII KWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQY LCNVRHIFTIPGQAFVPKPEVD VGVVHFTPLIQPKIEQPFKLVEKVVQ NVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISH FKSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL
    • 分子量
      39 kDa including tags
    • 氨基酸
      28 to 346
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab113141 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride, 0.02% DTT

常规信息

  • 别名
    • CGI75
    • Dimethyladenosine transferase 1, mitochondrial
    • h-mtTFB
    • h-mtTFB1
    • hmtTFB
    • hmtTFB1
    • hTFB1M
    • Mitochondrial 12S rRNA dimethylase 1
    • Mitochondrial dimethyladenosine transferase 1
    • Mitochondrial transcription factor B1
    • mtTFB1
    • N'-adenosyl(rRNA) dimethyltransferase 1
    • S-adenosylmethionine-6-N'
    • Tfb1m
    • TFB1M_HUMAN
    • Transcription factor B1 mitochondrial
    see all
  • 功能
    S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
  • 组织特异性
    Ubiquitously expressed.
  • 疾病相关
    Note=Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
  • 序列相似性
    Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt

Recombinant Human TFB1M protein 图像

  • 15% SDS-PAGE analysis of ab113141 (3µg)

Recombinant Human TFB1M protein (ab113141)参考文献

ab113141 has not yet been referenced specifically in any publications.

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