Recombinant人TEM8 protein (ab125985)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9H6X2
    • 种属Human
    • 分子量20 kDa
    • 氨基酸19 to 196

技术指标

Our Abpromise guarantee covers the use of ab125985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • Anthrax toxin receptor 1
    • ANTR1_HUMAN
    • Antxr1
    • ATR
    • Tumor endothelial marker 8
    see all
  • 功能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • 组织特异性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • 疾病相关Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • 序列相似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • 结构域Binding to PA occurs through the VWA domain.
  • 细胞定位Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt

Recombinant Human TEM8 protein (ab125985)参考文献

ab125985 has not yet been referenced specifically in any publications.

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