Recombinant人TCF4 protein (ab114441)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP15884
    • 种属Human
    • 序列MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNV EDRSSSGSWGNGGHPSPSRNYGDGTPYDHTTSRDLGSHDNLSPPFVNSRI QSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQ YSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPG YPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVG SPPSLSAGTAVWSRN
    • 分子量66 kDa including tags
    • 氨基酸1 to 365
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab114441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • bHLHb19
    • Class B basic helix-loop-helix protein 19
    • E2 2
    • Immunoglobulin transcription factor 2
    • ITF 2
    • ITF-2
    • ITF2
    • ITF2_HUMAN
    • MGC149723
    • MGC149724
    • PTHS
    • SEF 2
    • SEF-2
    • SEF2
    • SEF2 1
    • SEF2 1A
    • SEF2 1B
    • SL3 3 enhancer factor 2
    • SL3-3 enhancer factor 2
    • TCF 4
    • TCF-4
    • TCF4
    • Transcription factor 4
    see all
  • 功能Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
  • 组织特异性Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.
  • 疾病相关Defects in TCF4 are a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954]. PTHS is a rare syndromic encephalopathy characterized by severe psychomotor delay, epilepsy, daily bouts of diurnal hyperventilation starting in infancy, mild postnatal growth retardation, postnatal microcephaly, and distinctive facial features. Since most hitherto reported cases have been sporadic, with males and females equally affected, PTHS is regarded as an autosomal dominant condition.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 结构域the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human TCF4 protein 图像

  • ab114441 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human TCF4 protein (ab114441)参考文献

ab114441 has not yet been referenced specifically in any publications.

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