Recombinant人TCEB2 protein (ab81767)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ

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技术指标

Our Abpromise guarantee covers the use of ab81767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab81767 recombinant TCEB2 was expressed as insoluble protein aggregate in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M PMSF, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • EloB
    • ELOB_HUMAN
    • Elongin 18 kDa subunit
    • Elongin B
    • Elongin-B
    • RNA polymerase II transcription factor SIII p18 subunit
    • RNA polymerase II transcription factor SIII subunit B
    • SIII
    • SIII p18
    • TCEB 2
    • Tceb2
    • Transcription elongation factor B (SIII) polypeptide 2
    • Transcription elongation factor B polypeptide 2
    see all
  • 功能SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 ubiquitin-like domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human TCEB2 protein 图像

  • ab81767 on 15% SDS-PAGE (3µg)

Recombinant Human TCEB2 protein (ab81767)参考文献

ab81767 has not yet been referenced specifically in any publications.

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