Recombinant人TCEB2 protein (ab117680)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ15370
    • 种属Human
    • 序列MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCIEPFSSPPELP DVMKPQDSGS SANEQAVQ
    • 分子量13 kDa
    • 氨基酸1 to 118

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技术指标

Our Abpromise guarantee covers the use of ab117680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    TCEB2 is purified by standard chromatography techniques and filter sterilized.
  • 形式Liquid
  • 补充说明For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.02% PMSF, 20% Glycerol

常规信息

  • 别名
    • EloB
    • ELOB_HUMAN
    • Elongin 18 kDa subunit
    • Elongin B
    • Elongin-B
    • RNA polymerase II transcription factor SIII p18 subunit
    • RNA polymerase II transcription factor SIII subunit B
    • SIII
    • SIII p18
    • TCEB 2
    • Tceb2
    • Transcription elongation factor B (SIII) polypeptide 2
    • Transcription elongation factor B polypeptide 2
    see all
  • 功能SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 ubiquitin-like domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human TCEB2 protein (ab117680)参考文献

ab117680 has not yet been referenced specifically in any publications.

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