Recombinant人TCEB1 protein (ab114949)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ15369
    • 种属Human
    • 序列MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPG QFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIA LELLMAANFLDC
    • 分子量38 kDa including tags
    • 氨基酸1 to 112

技术指标

Our Abpromise guarantee covers the use of ab114949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Elo C
    • EloC
    • ELOC_HUMAN
    • Elongin 15 kDa subunit
    • Elongin C
    • Elongin-C
    • ElonginC
    • RNA polymerase II transcription factor SIII subunit C
    • SIII
    • SIII p15
    • TCEB 1
    • tceb1
    • Transcription elongation factor B (SIII) polypeptide 1
    • Transcription elongation factor B polypeptide 1
    see all
  • 功能SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • 组织特异性Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
  • 序列相似性Belongs to the SKP1 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human TCEB1 protein 图像

  • 12.5% SDS-PAGE showing ab114949 at approximately 38.06kDa.
    Stained with Coomassie Blue.

Recombinant Human TCEB1 protein (ab114949)参考文献

ab114949 has not yet been referenced specifically in any publications.

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