The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab125484 is purified by proprietary chromatographic techniques. Purity is greater than 80.0% as determined by SDS-PAGE.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
This is full length Isoform Tau-E, aa 1 to 412. P10636-7.
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Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
pH: 8.00 Constituents: 0.32% Tris HCl, 20% Glycerol
G protein beta1/gamma2 subunit interacting factor 1
Microtubule associated protein tau, isoform 4
Neurofibrillary tangle protein
Paired helical filament tau
相关性Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. There are nine named isoforms.
Defects in Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) [MIM:600274, 172700], pallido-ponto-nigral degeneration (PPND) [MIM:168610], corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) [MIM:601104, 260540], hereditary dysphasic disinhibition dementia (HDDD) [MIM:607485].
细胞定位Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Recombinant Human Tau412 protein (ab125484)参考文献
has not yet been referenced specifically in any publications.