Recombinant人Tau412 protein (ab125484)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP10636-7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEAEEAGIG DTPSLEDEAA GHVTQARMVS KSKDGTGSDD KKAKGADGKT KIATPRGAAP PGQKGQANAT RIPAKTPPAP KTPPSSGEPP KSGDRSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV RTPPKSPSSA KSRLQTAPVP MPDLKNVKSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS KCGSKDNIKH VPGGGSVQIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL
    • 分子量45 kDa including tags
    • 氨基酸1 to 412
    • 标签His tag N-Terminus
    • 额外的序列信息This is full length Isoform Tau-E, aa 1 to 412. P10636-7.

技术指标

Our Abpromise guarantee covers the use of ab125484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 80 % SDS-PAGE.
    ab125484 is purified by proprietary chromatographic techniques. Purity is greater than 80.0% as determined by SDS-PAGE.
  • 形式Liquid
  • 补充说明

    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

     

    This is full length Isoform Tau-E, aa 1 to 412. P10636-7.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • DDPAC
    • FTDP 17
    • FTDP17
    • G protein beta1/gamma2 subunit interacting factor 1
    • MAPTL
    • Microtubule associated protein tau, isoform 4
    • MSTD
    • MTBT1
    • MTBT2
    • Neurofibrillary tangle protein
    • Paired helical filament tau
    • PHF tau
    • TAU
    see all
  • 相关性Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. There are nine named isoforms. Defects in Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) [MIM:600274, 172700], pallido-ponto-nigral degeneration (PPND) [MIM:168610], corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) [MIM:601104, 260540], hereditary dysphasic disinhibition dementia (HDDD) [MIM:607485].
  • 细胞定位Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Recombinant Human Tau412 protein (ab125484)参考文献

ab125484 has not yet been referenced specifically in any publications.

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