G protein beta1/gamma2 subunit-interacting factor 1
Microtubule associated protein tau
Microtubule-associated protein tau, isoform 4
Tau381 promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cell Membrane and Cytoplasmic
SDS-PAGE - Tau381 protein (Human) (ab84770)
SDS-PAGE showing ab84770 at approximately 54kDa.
has not yet been referenced specifically in any publications.