Recombinant人SUZ12 protein (ab112401)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      VENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLE KGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL
    • 分子量
      37 kDa including tags
    • 氨基酸
      640 to 739

相关产品

技术指标

Our Abpromise guarantee covers the use of ab112401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

    Other

  • 形式
    Liquid
  • 补充说明
    Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • ChET 9 protein
    • CHET9
    • Chromatin precipitated E2F target 9 protein
    • JJAZ1
    • Joined to JAZF1 protein
    • KIAA0160
    • Polycomb protein SUZ12
    • Suppressor of zeste 12 homolog
    • Suppressor of zeste 12 protein homolog
    • SUZ12
    • SUZ12 polycomb repressive complex 2 subunit
    • SUZ12_HUMAN
    see all
  • 功能
    Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
  • 组织特异性
    Overexpressed in breast and colon cancer.
  • 疾病相关
    Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.
  • 序列相似性
    Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
    Contains 1 C2H2-type zinc finger.
  • 发展阶段
    Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab112401. Stained with Coomassie Blue

文献

ab112401 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab112401.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册