Recombinant人SUV420h1 protein (ab80286)

概述

  • 产品名称
    Recombinant人SUV420h1 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      2 to 387

技术指标

Our Abpromise guarantee covers the use of ab80286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

常规信息

  • 别名
    • CGI 85
    • CGI85
    • Histone-lysine N-methyltransferase KMT5B
    • Kmt5b
    • KMT5B_HUMAN
    • Lysine N-methyltransferase 5B
    • Lysine-specific methyltransferase 5B
    • MGC118906
    • MGC118909
    • MGC21161
    • MGC703
    • Su(var)4-20 homolog 1
    • Suppressor of variegation 4 20 homolog 1
    • Suppressor of variegation 4-20 homolog 1
    • Suv4-20h1
    see all
  • 功能
    Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
  • 序列相似性
    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
    Contains 1 SET domain.
  • 细胞定位
    Nucleus. Chromosome. Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
  • Information by UniProt

Recombinant Human SUV420h1 protein 图像

  • SDS-PAGE showing ab80286 at approximately 70kDa (3µg).

Recombinant Human SUV420h1 protein (ab80286)参考文献

ab80286 has not yet been referenced specifically in any publications.

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