Recombinant人Suppressor of Ty 4 homolog 1 protein (ab116941)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP63272
    • 种属Human
    • 序列MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVY DCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRE LKSRGVAYKSRDTAIKT
    • 分子量39 kDa including tags
    • 氨基酸1 to 117

技术指标

Our Abpromise guarantee covers the use of ab116941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DRB sensitivity-inducing factor 14 kDa subunit
    • DRB sensitivity-inducing factor small subunit
    • DSIF p14
    • DSIF small subunit
    • hSPT4
    • SPT4
    • SPT4H
    • SPT4H_HUMAN
    • SUPT4H
    • SUPT4H `1
    • Supt4h1
    • Transcription elongation factor spt4
    see all
  • 功能Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the SPT4 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human Suppressor of Ty 4 homolog 1 protein 图像

  • ab116941 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Suppressor of Ty 4 homolog 1 protein (ab116941)参考文献

ab116941 has not yet been referenced specifically in any publications.

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