Recombinant人Sumo 2 protein (ab86444)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGG

技术指标

Our Abpromise guarantee covers the use of ab86444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab86444 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • HSMT 3
    • HSMT3
    • MGC117191
    • Sentrin 2
    • Sentrin-2
    • Sentrin2
    • Small ubiquitin like modifier 2
    • Small ubiquitin related modifier 2
    • Small ubiquitin-related modifier 2
    • SMT 3B
    • SMT3 homolog 2
    • SMT3 suppressor of mif two 3 homolog 2
    • SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
    • SMT3, yeast, homolog 2
    • Smt3A
    • SMT3B
    • SMT3H2
    • SUMO-2
    • SUMO-3
    • SUMO2
    • SUMO2_HUMAN
    • Sumo3
    • Ubiquitin like protein SMT3B
    • Ubiquitin-like protein SMT3A
    see all
  • 功能Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
  • 组织特异性Broadly expressed.
  • 序列相似性Belongs to the ubiquitin family. SUMO subfamily.
    Contains 1 ubiquitin-like domain.
  • 翻译后修饰Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
    Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • 细胞定位Nucleus. Nuclear bodies.
  • Information by UniProt

Recombinant Human Sumo 2 protein 图像

  • 15% SDS-PAGE showing ab86444 at approximately 18kDa (3µg).

Recombinant Human Sumo 2 protein (ab86444)参考文献

ab86444 has not yet been referenced specifically in any publications.

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