Recombinant人Sumo 2 protein (ab73446)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYC ERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY.
    • 分子量11 kDa

技术指标

Our Abpromise guarantee covers the use of ab73446 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab73446 is is purified by proprietary chromatographic techniques. Purity is greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 1X PBS, pH 7.4

常规信息

  • 别名
    • HSMT 3
    • HSMT3
    • MGC117191
    • Sentrin 2
    • Sentrin-2
    • Sentrin2
    • Small ubiquitin like modifier 2
    • Small ubiquitin related modifier 2
    • Small ubiquitin-related modifier 2
    • SMT 3B
    • SMT3 homolog 2
    • SMT3 suppressor of mif two 3 homolog 2
    • SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
    • SMT3, yeast, homolog 2
    • Smt3A
    • SMT3B
    • SMT3H2
    • SUMO-2
    • SUMO-3
    • SUMO2
    • SUMO2_HUMAN
    • Sumo3
    • Ubiquitin like protein SMT3B
    • Ubiquitin-like protein SMT3A
    see all
  • 功能Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
  • 组织特异性Broadly expressed.
  • 序列相似性Belongs to the ubiquitin family. SUMO subfamily.
    Contains 1 ubiquitin-like domain.
  • 翻译后修饰Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
    Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • 细胞定位Nucleus. Nuclear bodies.
  • Information by UniProt

Recombinant Human Sumo 2 protein (ab73446)参考文献

ab73446 has not yet been referenced specifically in any publications.

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