Recombinant人Stromal interaction molecule 1 protein (ab78681)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SMLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKD
      underlined sequence is the CaM tag.
    • 氨基酸23 to 213

技术指标

Our Abpromise guarantee covers the use of ab78681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab78681 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Tris, pH 7.5

常规信息

  • 别名
    • D11S4896E
    • GOK
    • OTTHUMP00000164512
    • OTTHUMP00000229140
    • OTTHUMP00000230742
    • SIM
    • STIM 1
    • STIM1
    • Stim1 stromal interaction molecule 1
    • STIM1_HUMAN
    • STIM1L
    • Stromal interaction molecule 1
    see all
  • 功能Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
  • 组织特异性Ubiquitously expressed in various human primary cells and tumor cell lines.
  • 疾病相关Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
  • 序列相似性Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻译后修饰Glycosylation is required for cell surface expression.
    Phosphorylated predominantly on Ser residues.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
  • Information by UniProt

Recombinant Human Stromal interaction molecule 1 protein 图像

  • 15% SDS-PAGE showing ab68681 at approximately 38kDa (3µg).

Recombinant Human Stromal interaction molecule 1 protein (ab78681)参考文献

ab78681 has not yet been referenced specifically in any publications.

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