Recombinant人Stromal interaction molecule 1 protein (ab117174)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQ DMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGY ISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAKG SMLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRN IHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDL WKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVT NTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKD
    • 分子量
      38 kDa
    • 氨基酸
      19 to 213

技术指标

Our Abpromise guarantee covers the use of ab117174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    HPLC

  • 纯度
    > 90 % SDS-PAGE.
    ab117174 is purified by conventional chromatography techniques. Purity is greater than 90.0% as determined by RP-HPLC and SDS-PAGE.
  • 形式
    Liquid
  • 补充说明
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituent: 0.24% Tris

常规信息

  • 别名
    • D11S4896E
    • GOK
    • OTTHUMP00000164512
    • OTTHUMP00000229140
    • OTTHUMP00000230742
    • SIM
    • STIM 1
    • STIM1
    • Stim1 stromal interaction molecule 1
    • STIM1_HUMAN
    • STIM1L
    • Stromal interaction molecule 1
    see all
  • 功能
    Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
  • 组织特异性
    Ubiquitously expressed in various human primary cells and tumor cell lines.
  • 疾病相关
    Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
  • 序列相似性
    Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域
    The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻译后修饰
    Glycosylation is required for cell surface expression.
    Phosphorylated predominantly on Ser residues.
  • 细胞定位
    Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
  • Information by UniProt

文献

ab117174 has not yet been referenced specifically in any publications.

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