概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF
    • 氨基酸1 to 98

技术指标

Our Abpromise guarantee covers the use of ab78799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    Purity is > 98% by SDS PAGE. ab78799 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Sodium chloride, 20mM Tris, pH 8.0

常规信息

  • 别名
    • CHROW21
    • CPI B
    • CPI-B
    • CST 6
    • CST6
    • CSTB
    • Cystatin B
    • Cystatin B (stefin B)
    • Cystatin-B
    • CYTB
    • CYTB_HUMAN
    • EPM1
    • EPM1A
    • Liver thiol proteinase inhibitor
    • PME
    • Stefin-B
    • STF B
    • STFB
    • ULD
    see all
  • 功能This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
  • 疾病相关Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) [MIM:254800]. EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop.
  • 序列相似性Belongs to the cystatin family.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human Stefin B protein 图像

  • 15% SDS-PAGE showing ab78799 at approximately 13kDa (3µg).

Recombinant Human Stefin B protein (ab78799)参考文献

This product has been referenced in:
  • Mandal P  et al. H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure. FEBS J 281:5292-308 (2014). Read more (PubMed: 25263734) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab78799.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"