Recombinant人Stathmin 1 protein (ab87492)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
    • 标签His tag N-Terminus
    • 额外的序列信息This protein contains a thrombin cleavage site.

技术指标

Our Abpromise guarantee covers the use of ab87492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 95 % SDS-PAGE.
    ab87492 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • C1orf215
    • Lag
    • LAP 18
    • LAP18
    • Leukemia associated phosphoprotein p18
    • Leukemia-associated phosphoprotein p18
    • Metablastin
    • Oncoprotein 18
    • OP 18
    • Op18
    • p18
    • p19
    • Phosphoprotein 19
    • Phosphoprotein p19
    • pp17
    • pp19
    • PR22
    • Pr22 protein
    • Prosolin
    • Protein Pr22
    • SMN
    • Stathmin
    • Stathmin1
    • STMN 1
    • Stmn1
    • STMN1_HUMAN
    see all
  • 功能Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • 组织特异性Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
  • 序列相似性Belongs to the stathmin family.
    Contains 1 SLD (stathmin-like) domain.
  • 翻译后修饰Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Stathmin 1 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab87492.

Recombinant Human Stathmin 1 protein (ab87492)参考文献

ab87492 has not yet been referenced specifically in any publications.

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