Recombinant人Stathmin 1 protein (ab125559)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP16949
    • 种属Human
    • 分子量19 kDa
    • 氨基酸1 to 149
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 90 % Densitometry.
    ab125559 is >90% pure.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 1.75% Sodium chloride, 25% Glycerol, 0.004% DTT, 0.81% Sodium phosphate, 0.002% PMSF

常规信息

  • 别名
    • C1orf215
    • Lag
    • LAP 18
    • LAP18
    • Leukemia associated phosphoprotein p18
    • Leukemia-associated phosphoprotein p18
    • Metablastin
    • Oncoprotein 18
    • OP 18
    • Op18
    • p18
    • p19
    • Phosphoprotein 19
    • Phosphoprotein p19
    • pp17
    • pp19
    • PR22
    • Pr22 protein
    • Prosolin
    • Protein Pr22
    • SMN
    • Stathmin
    • Stathmin1
    • STMN 1
    • Stmn1
    • STMN1_HUMAN
    see all
  • 功能Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • 组织特异性Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
  • 序列相似性Belongs to the stathmin family.
    Contains 1 SLD (stathmin-like) domain.
  • 翻译后修饰Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Stathmin 1 protein 图像

  • SDS PAGE analysis of ab125559 (Stathmin 1 protein).

Recombinant Human Stathmin 1 protein (ab125559)参考文献

ab125559 has not yet been referenced specifically in any publications.

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