Recombinant人StAR protein (ab115707)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP49675
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMEETLYSDQELAYLQQGEEAMQKALGILSN QEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERME AMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKR RGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWL LSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC
    • 分子量27 kDa including tags
    • 氨基酸64 to 285
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab115707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab115707 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.03% DTT

常规信息

  • 别名
    • Cholesterol trafficker
    • Luteinizing hormone induced protein
    • mitochondrial
    • Mitochondrial steroid acute regulatory protein
    • StAR
    • StAR related lipid transfer (START) domain containing 1
    • STAR_HUMAN
    • StARD1
    • START domain containing 1
    • START domain containing protein 1
    • START domain-containing protein 1
    • Steroid acute regulatory protein
    • Steroidogenic acute regulator
    • Steroidogenic acute regulatory protein
    • Steroidogenic acute regulatory protein mitochondrial
    see all
  • 功能Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
  • 组织特异性Expressed in gonads, adrenal cortex and kidney.
  • 通路Steroid metabolism; cholesterol metabolism.
  • 疾病相关Defects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
  • 序列相似性Contains 1 START domain.
  • 细胞定位Mitochondrion.
  • Information by UniProt

Recombinant Human StAR protein 图像

  • 15% SDS-PAGE showing ab115707 at approximately 27.1kDa (3µg).

Recombinant Human StAR protein (ab115707)参考文献

ab115707 has not yet been referenced specifically in any publications.

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