Recombinant人SQSTM1 / p62 protein (ab117208)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ13501
    • 种属Human
    • 序列MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH
    • 分子量40 kDa including tags
    • 氨基酸1 to 356
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • 补充说明Although stable at 4°C for 1 week, ab117208 should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • A170
    • EBI 3 associated protein of 60 kDa
    • EBI 3 associated protein p60
    • EBI3 associated protein of 60 kDa
    • EBI3 associated protein p60
    • EBI3-associated protein of 60 kDa
    • EBIAP
    • FTDALS3
    • MGC127197
    • ORCA
    • OSF-6
    • Osi
    • OSIL
    • Oxidative stress induced like
    • p60
    • p62
    • p62B
    • Paget disease of bone 3
    • PDB 3
    • PDB3
    • Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa
    • Phosphotyrosine independent ligand for the Lck SH2 domain p62
    • Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
    • PKC-zeta-interacting protein
    • Protein kinase C-zeta-interacting protein
    • Sequestosome 1
    • Sequestosome-1
    • SQSTM 1
    • SQSTM_HUMAN
    • Sqstm1
    • STAP
    • STONE14
    • Ubiquitin binding protein p62
    • Ubiquitin-binding protein p62
    • ZIP
    • ZIP 3
    • ZIP3
    see all
  • 功能Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.
  • 序列相似性Contains 1 OPR domain.
    Contains 1 UBA domain.
    Contains 1 ZZ-type zinc finger.
  • 结构域The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55.
    The OPR domain mediates homooligomerization and interactions with PRKCZ, PRKCI, MAP2K5 and NBR1.
    The ZZ-type zinc finger mediates the interaction with RIPK1.
  • 翻译后修饰Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.
  • 细胞定位Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
  • Information by UniProt

Recombinant Human SQSTM1 / p62 protein (ab117208)参考文献

ab117208 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. Theoretically this protein can be used as a control, although of course we have not tested it and cannot guarantee it. This product has was used as the immunogen for another antibody to SQSTM1/p62 and run on SDS-PAGE for pr...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"