Recombinant人SPR protein (ab86445)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF KSGAHVDFYD K

技术指标

Our Abpromise guarantee covers the use of ab86445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab86445 is purified using conventional chromatography techniques.
  • 形式Liquid
  • 补充说明Endotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • OTTHUMP00000160199
    • SDR38C1
    • Sepiapterin reductase
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase)
    • Short chain dehydrogenase/reductase family 38C, member 1
    • SPR
    • SPRE_HUMAN
    see all
  • 功能Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 疾病相关Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 序列相似性Belongs to the sepiapterin reductase family.
  • 翻译后修饰In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human SPR protein 图像

  • 15% SDS-PAGE showing ab86445 at approximately 30.2kDa (3µg).

Recombinant Human SPR protein (ab86445)参考文献

ab86445 has not yet been referenced specifically in any publications.

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