The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
LDLR relative with 11 ligand binding repeats
LDLR relative with 11 ligand-binding repeats
Low density lipoprotein receptor relative with 11 ligand binding repeats
Low-density lipoprotein receptor relative with 11 ligand-binding repeats
Mosaic protein LR11
Sortilin related receptor
Sortilin related receptor L(DLR class) A repeats containing
Sorting protein related receptor containing LDLR class A repeats
Sorting protein-related receptor containing LDLR class A repeats
功能Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
组织特异性Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
序列相似性Belongs to the SORL1 family. Contains 5 BNR repeats. Contains 1 EGF-like domain. Contains 6 fibronectin type-III domains. Contains 11 LDL-receptor class A domains. Contains 5 LDL-receptor class B repeats.
翻译后修饰The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.